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eCAM Advance Access originally published online on March 15, 2007
eCAM 2008 5(2):181-186; doi:10.1093/ecam/nem017
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© 2007 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Evaluation of the anxiolytic effect of Nepeta persica Boiss. in mice

M. Rabbani1, S. E. Sajjadi2 and A. Mohammadi3

1Department of Pharmacology, 2Department of Pharmacognosy and 3Isfahan Pharmaceutical Sciences Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

The aim of the present study was to evaluate the anxiolytic effects of hydroalcoholic extract (HE) of Nepeta persica Boiss. (Lamiaceae) on the elevated plus-maze (EPM) model of anxiety. The extract of arial parts of the plant was administered intraperitoneally to male NMRI mice, at various doses, 30 min before behavioural evaluation. The HE extract of N. persica at the dose of 50 mg kg–1 significantly increased the percentage of time spent and percentage of arm entries in the open arms of the EPM. This dose of plant extract affected neither animal's locomotor activity nor ketamine-induced sleeping time. The 50 mg kg–1 dose of the plant extract seemed to be the optimal dose in producing the anxiolytic effects, lower or higher doses of the plant produce either sedative or stimulant effects. At 100 mg kg–1, the plant extract increased the locomotor activity. These results suggested that the extract of N. persica at dose of 50 mg kg–1 possess anxiolytic effect with less sedative and hypnotic effects than that of diazepam and causes a non-specific stimulation at 100 mg kg–1.

Keywords: anxiety – elevated plus-maze – Nepeta persica – sedative

For reprints and all correspondence: Dr Mohammed Rabbani, Isfahan University of Medical Sciences, School of Pharmacy and Pharmaceutical Sciences, Hezar Jirib Av., Isfahan 81745-359, Iran. Tel: +98-311-7922646; Fax: +98-311-6680011; E-mail: rabanim{at}yahoo.com; rabbani{at}pharm.mui.ac.ir

Received July 15, 2006; accepted January 16, 2007


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